{"id":1498,"date":"2007-11-30T18:38:53","date_gmt":"2007-11-30T22:38:53","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=1498"},"modified":"2007-11-30T18:38:53","modified_gmt":"2007-11-30T22:38:53","slug":"breve-revision-de-enfermedad-de-darier","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/1498","title":{"rendered":"Breve revisi\u00f3n de Enfermedad de Darier"},"content":{"rendered":"<p><strong>Autor: Paula Soto.<br \/> Residente de primer a\u00f1o del Hospital Vargas.<br \/> Instituto de Biomedicina Caracas Venezuela<\/strong>&nbsp; <\/p>\n<ul>\n<li>\n<p>Genodermatosis \tautos\u00f3mica dominante<\/p>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<p>Algunos casos sin \tantecedentes familiares&nbsp;<\/p>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<p>H:M es igual<\/p>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<p>Mutaci\u00f3n de gen ATP2A2 en \tel cromosoma 12<\/p>\n<\/li>\n<\/ul>\n<p>(Interifere con se\u00f1alizaci\u00f3n intracelular de calcio)<\/p>\n<p><!--more--> <\/p>\n<p>Histopatolog\u00eda:<\/p>\n<ul>\n<li>\n<p>Disqueratosis \tacantol\u00edtica:<\/p>\n<\/li>\n<\/ul>\n<p>&#8211; Fisurizaci\u00f3n suprabasal con c\u00e9lulas acantol\u00edticas y disquerat\u00f3sicas a todos los niveles de la epidermis<\/p>\n<p>Diagn\u00f3stico Diferencial:<\/p>\n<ul>\n<ul>\n<li>\n<p>Dermatitis \t\tseborreica severa<\/p>\n<\/li>\n<li>\n<p>Enfermedad de Grover<\/p>\n<\/li>\n<li>\n<p>P\u00e9nfigo \t\tbenigno familiar<\/p>\n<\/li>\n<\/ul>\n<\/ul>\n<p>(Enfermedad de Hailey-Hailey)<\/p>\n<p>Tratamiento:<\/p>\n<p>Medidas generales:<\/p>\n<p>Ropa<\/p>\n<p>Fotoprotecci\u00f3n<\/p>\n<p>Cuidado diario<\/p>\n<p>Emolientes<\/p>\n<p>T\u00f3pico:<\/p>\n<p>Corticoides<\/p>\n<p>Tretinoina: 0.05%<\/p>\n<p>Tazaroteno 0.07%<\/p>\n<p>Adapalene 0.1%<\/p>\n<p>Sist\u00e9mico:<\/p>\n<p>RETINOIDES ORALES:<\/p>\n<p>ISOTRETINOINA 0.5 a 1 mg\/kg\/d<\/p>\n<p>ACITRETINA 0.25 a 0.5 mg\/kg\/d<\/p>\n<p>CICLOSPORINA<\/p>\n<p>Quir\u00fargico:<\/p>\n<p>EXCISION SEGUIDA DE:<\/p>\n<p>INJERTO<\/p>\n<p>DERMOABRASION<\/p>\n<p>EXTIRPACI\u00d3N CON LASER CO2 O ERBIO<\/p>\n<p>Referencias Bibliogr\u00e1ficas:<\/p>\n<p>Rodr\u00edguez A, Aparicio G, Ramos- Garibay A .Enfermedad de Darier: Presentaci\u00f3n de un caso .Rev Cent Dermatol Pascua 2004; 13 (3):150-153<\/p>\n<p>2. O&#39;Malley M, Haake A, Goldsmith L, Berg D. Localized Darier disease. Archives of Dermatology, 1997;133:1134-1138<\/p>\n<p>3. Bolognia J, Jorizzo J, Rapini R.Enfermedad de Darier y Enfermedad de Haley-Haley en: Elsiever Science Limited, editors. Dermatolog\u00eda; 2004 p. 823-833<\/p>\n<p>4. Burge S,  Wilkinson J. Darier-White disease: a review of the clinical features in 163 patients. Journal of the American Academy of Dermatology (JAAD).  1992; 27(1) :40-50<\/p>\n<p>5. Craig G. Burkhart, MSPH, MDa, Craig N. Burkhartb. Tazarotene gel for Darier&#39;s disease . Journal of the American Academy of Dermatology (JAAD)  1998; (1)6: 1001-1002<em> <\/em><\/p>\n<p>6. Beier C; Kaufmann R .Efficacy of Erbium:YAG Laser Ablation in Darier Disease and Hailey-Hailey DiseaseArch Dermatol, Apr 1999; 135: 423-427.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autor: Paula Soto. Residente de primer a\u00f1o del Hospital Vargas. Instituto de Biomedicina Caracas Venezuela&nbsp; Genodermatosis autos\u00f3mica dominante Algunos casos sin antecedentes familiares&nbsp; H:M es igual Mutaci\u00f3n de gen ATP2A2 en el cromosoma 12 (Interifere con se\u00f1alizaci\u00f3n intracelular de calcio)<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-1498","post","type-post","status-publish","format-standard","","category-fichas-bibliograficas"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/1498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=1498"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/1498\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=1498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=1498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=1498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}