{"id":2000,"date":"2008-02-08T11:56:44","date_gmt":"2008-02-08T15:56:44","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=2000"},"modified":"2008-02-08T11:56:44","modified_gmt":"2008-02-08T15:56:44","slug":"uso-de-talidomida-en-dermatologia-pediatrica","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/2000","title":{"rendered":"Uso de Talidomida en Dermatolog\u00eda Pedi\u00e1trica"},"content":{"rendered":"<p><strong>Por Carmen Kannee<\/strong><\/p>\n<ul>\n<li>1954 sintetizada por Laboratorio Gr&uuml;nenthal. Alemania Occidental<\/li>\n<\/ul>\n<p><em>Uso de Talidomida en Ni\u00f1os<\/em><\/p>\n<ul>\n<li>1957 disponible a la venta en Alemania, como sedante y antiem\u00e9tico (embarazo)<\/li>\n<li>1957-1958 distribuci\u00f3n en resto de Europa Asia, Africa y Suram\u00e9rica<\/li>\n<li>1960 primera publicaci\u00f3n de caso con neuropat\u00eda perif\u00e9rica<\/li>\n<li>1998 aprobada por FDA para ENL<\/li>\n<li>Uso en variedad de enfermedades inflamatorias y c\u00e1ncer<\/li>\n<li>Investigaci\u00f3n sobre su mecanismo de acci\u00f3n<\/li>\n<li>2006 aprobada por FDA para Mieloma M\u00faltiple<\/li>\n<\/ul>\n<p> <!--more--> <\/p>\n<p><em>&nbsp;<\/em><\/p>\n<p><em><u>Modo de accion<\/u><\/em><\/p>\n<ul>\n<li>Inmunomodulador<\/li>\n<\/ul>\n<ul>\n<li>Anti-inflamatorio<\/li>\n<\/ul>\n<ul>\n<li>Inhibici\u00f3n de angiog\u00e9nesis<\/li>\n<\/ul>\n<ul>\n<li><u>Efectos indeseables<\/u><\/li>\n<li><u>Graves<\/u><\/li>\n<\/ul>\n<p>-Teratog\u00e9nesis<\/p>\n<ul>\n<li><u>Frecuentes<\/u><\/li>\n<\/ul>\n<p>-Sedaci\u00f3n<\/p>\n<p>-Constipaci\u00f3n<\/p>\n<p>-Neuropat\u00eda perif\u00e9rica<\/p>\n<p>-Rash<\/p>\n<p>-Tromboembolismo<\/p>\n<p>-V\u00e9rtigo<\/p>\n<p><em><u>Indicaciones en Ni\u00f1os<\/u><\/em><\/p>\n<ul>\n<li>Estomatitis Aftosa<\/li>\n<\/ul>\n<p>&#8211;<em>Menni S, et al. Recurrent giant aphtous ulcers in a child: protracted treatment with thalidomide. <\/em><em>Ped Dermatol 1993;10:283-285<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<ul>\n<li>Estomatitis Aftosa en pacientes con SIDA<\/li>\n<\/ul>\n<p>&#8211;<em>De Vincenzo J, et al.&nbsp; <\/em><em>Prolonged thalidomide therapy for human inmunodeficiency virus\/associated recurrent severe esophageal and oral aphtous ulcers. <\/em><em>Ped Infect Dis J 1996;15:465-467<\/em><\/p>\n<ul>\n<li>Enfermedad de Beh&ccedil;et Infantil<\/li>\n<\/ul>\n<p>&#8211;<em>Shek L, et al. Thalidomide response in an infant with Beh&ccedil;et syndrome. Pediatrics 1999;103:1295-1297<\/em><em> <\/em><\/p>\n<p>&#8211;<em>Brik R, et al.&nbsp; Successful thalidomide treatment of severe infantile Beh&ccedil;et disease.&nbsp; Ped Dermatol 2001;143-145<\/em><\/p>\n<ul>\n<li>Dosis: 20mg\/Kg\/d\u00eda<\/li>\n<\/ul>\n<p>&#8211;<em>Beh&ccedil;et&#39;s disease in UK children: clinical features and treatment including thalidomide. Rheumatology 2001;40:933-938<\/em><\/p>\n<ul>\n<li>Dosis: 1mg\/kg\/semana hasta 1mg\/kg\/d\u00eda<\/li>\n<\/ul>\n<ul>\n<li>Prurigo Act\u00ednico<\/li>\n<\/ul>\n<p>&#8211;<em>Cazar\u00edn J, et al.&nbsp; Talidomida en ni\u00f1os con prurigo solar refractario. Actas Dermatol 2002;2:11-15<\/em><\/p>\n<p>&#8211;<em>Lowell C, et al. Thalidomide in actinic prurigo. <\/em><em>Br J Dermatol 1983;108:467<\/em><\/p>\n<p>&#8211;<em>Boggio P, et al. Prurigo act\u00ednico: a prop\u00f3sito de un caso. Arch argent pediatr 2006;104:530-532<\/em><\/p>\n<p>&#8211;<em>Ng J, et al. A case of severe actinic prurigo successfully treated with thalidomide. <\/em><em>Australas J Dermatol 2001;42:192-195<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<ul>\n<li>Enfermedad injerto contra hu\u00e9sped cr\u00f3nica<\/li>\n<\/ul>\n<p>&#8211;<em>Rovelli A, et al.&nbsp; The role of thalidomide in the treatment of refractory chronic graft-versus host disease following bone marrow transplantation in children. <\/em><em>Bone Marrow Transplant 1998;21:577-581<\/em><\/p>\n<p>&#8211;<em>Cole C, et al. Thalidomide in the management of chronic graft-versus host disease in children following bone marrow transplantation: series at a single institution and review of the literature. <\/em><em>Bone Marrow Transplant 1994;14:937-942<\/em><\/p>\n<p>&#8211;<em>Metha P, et al. Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature. <\/em><em>Pediatrics 1999;103:E44<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<ul>\n<li>Lupus Eritematoso cut\u00e1neo<\/li>\n<\/ul>\n<p>&#8211;<em>Ordi-Ros J, et al. <\/em><em>Thalidomide in the treatment of cutaneous lupus erythematosus refractory to conventional theraphy. <\/em><em>J Rheumatol 2000;27:1429<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<p>&#8211;<em>Sampaio M. Lupus eritematoso disc\u00f3ide na inf<\/em><em>&acirc;<\/em><em>ncia. Rev paul pediatr;25:167-17<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<p>&#8211;<em>Moises-Alfaro C, et al.&nbsp; <\/em><em>Discoid Lupus Erythematosus in children. <\/em><em>Ped Dermatol 2003;20:103-107<\/em><\/p>\n<ul>\n<li>Dermatitis At\u00f3pica Severa<\/li>\n<\/ul>\n<p>&#8211;<em>Mendes A, et al. Talidomida no tratamiento de pacientes com Dermatite At\u00f3pica Grave: estudio retrospectivo de 14 casos. Rev bras alergia imunopatol 2005;28:245-248<\/em><\/p>\n<p><em>&nbsp;<\/em><\/p>\n<p>&#8211;<em>Sosa M, et al. Comparision between thalidomide and transfer factor in severe atopic dermatitis. <\/em><em>Rev Alerg Mex 2001;48:56-64.<\/em><\/p>\n<p><em>Uso de Talidomida en Ni\u00f1os<\/em><\/p>\n<ul>\n<li>Pioderma Gangrenoso<\/li>\n<\/ul>\n<p><u>Forma de uso<\/u><\/p>\n<ul>\n<li>Selecci\u00f3n adecuada del caso<\/li>\n<li>Dosis m\u00ednima efectiva<\/li>\n<li>Precauciones para evitar embarazo<\/li>\n<li>Monitorizar neuropat\u00eda perif\u00e9rica<\/li>\n<\/ul>\n<p>-S\u00edntomas<\/p>\n<p>-Examen f\u00edsico neurol\u00f3gico<\/p>\n<p>-Estudios neurofisiol\u00f3gicos<\/p>\n<ul>\n<li><u>Nuevas Drogas derivados de la Talidomida<\/u><\/li>\n<li>inmunomoduladoras imidas (IMiDs)<\/li>\n<\/ul>\n<p>-Inhibidores de TNF-a, IL1b, IL-12, IL-6<\/p>\n<p>-Activaci\u00f3n de linfocitos T<\/p>\n<p>-Ej: lenalidomide (Revlimid;CC-5013) y Actimid;CC-4047<\/p>\n<p>&#8211;<u>Uso potencial<\/u>:&nbsp; anti-neopl\u00e1siocs, infecci\u00f3n por VIH<\/p>\n<ul>\n<li>Drogas inhibitorias selectivas de citocinas (SelCDis)<\/li>\n<\/ul>\n<p>-Inhibidores de la PDE4, TNF-a, IL-12<\/p>\n<p>-Inhibidores o ning\u00fan efecto en activaci\u00f3n de linfocitos T<\/p>\n<p>&#8211;<u>Uso potencial<\/u>:&nbsp; enfermedades inflamatorias (asma, DA, enfermedad inflamatoria intestinal, artritis reumatoide)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Por Carmen Kannee 1954 sintetizada por Laboratorio Gr&uuml;nenthal. Alemania Occidental Uso de Talidomida en Ni\u00f1os 1957 disponible a la venta en Alemania, como sedante y antiem\u00e9tico (embarazo) 1957-1958 distribuci\u00f3n en resto de Europa Asia, Africa y Suram\u00e9rica 1960 primera publicaci\u00f3n de caso con neuropat\u00eda perif\u00e9rica 1998 aprobada por FDA para ENL Uso en variedad de &hellip;<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[],"class_list":["post-2000","post","type-post","status-publish","format-standard","","category-conferencias"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/2000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=2000"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/2000\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=2000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=2000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=2000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}