{"id":2537,"date":"2008-05-09T21:45:23","date_gmt":"2008-05-10T01:45:23","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=2537"},"modified":"2008-05-09T21:48:53","modified_gmt":"2008-05-10T01:48:53","slug":"a-follow-up-study-of-recurrence-and-cosmesis-in-completely-responding-superficial-and-nodular-bcc-treated-with-mal-based-pdt-alone-and-with-prior-curettage","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/2537","title":{"rendered":"A follow up study of recurrence and cosmesis in completely responding superficial and nodular BCC treated with MAL-based PDT alone and with prior curettage"},"content":{"rendered":"<p><strong>A.M.SOLER, T.WARLOE, A.BERNER* AND K.E.GIERCKSKY<br \/> Photodynamic Out-Patient Clinic, Department of Surgical Oncology, and *Department of Pathology, The Norwegian Radium Hospital,<br \/> Montebello, N-0310 Oslo, Norway<br \/> Accepted for publication 27 April 2001<\/strong><\/p>\n<p><!--more--> <\/p>\n<p>Summary<\/p>\n<p>Background Methyl 5-aminolaevulinate (mALA) is an ester derivative of 5-aminolaevulinic acid<br \/> (ALA) with increased lipophilicity compared with ALA. <\/p>\n<p>Objectives<\/p>\n<p>To assess long-term cure rate, cosmesis, recurrence rate and extent of fibrosis after mALA-based photodynamic therapy (PDT) of superficial and nodular basal cell carcinomas (BCCs) showing early complete response to treatment.<\/p>\n<p>Methods Of 350 BCCs treated, 310 responded completely. These were in 59 patients who were followed for 2&plusmn;4 years (mean 35 months) after mALA-PDT. Nodular tumours were curetted before PDT, and mALA 160 mg g21 was applied to all tumours for 24 h or 3 h before illumination from a broad-band halogen light source with light doses from 50 to 200 J cm22. Fibrosis was assessed histologically in 23 biopsies.<\/p>\n<p>Results<\/p>\n<p>The overall cure rate for 350 BCCs, including non-responders and recurrences was 79%. Of 310 lesions, 277 (89%) remained in complete response, and the cosmetic outcome was excellent or good in 272 of the completely responding lesions (98%). Histological examination showed dermal fibrosis in one of 23 biopsies.<\/p>\n<p>Conclusions<\/p>\n<p>We conclude that mALA-based PDT with prior curettage of nodular lesions is a promising new method for the treatment of BCC.<\/p>\n<p>Key words: basal cell carcinoma, broad-band halogen lamp, methyl 5-aminolaevulinate, photodynamic therapy&nbsp;<\/p>\n<p><strong>Descargue art\u00edculo completo: <a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/2008\/03\/193\/piel-l-020408.pdf\" title=\"piel-l-020408.pdf\">piel-l-020408.pdf<\/a> <\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A.M.SOLER, T.WARLOE, A.BERNER* AND K.E.GIERCKSKY Photodynamic Out-Patient Clinic, Department of Surgical Oncology, and *Department of Pathology, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway Accepted for publication 27 April 2001<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-2537","post","type-post","status-publish","format-standard","","category-notigalderma"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/2537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=2537"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/2537\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=2537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=2537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=2537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}