{"id":25849,"date":"2012-04-14T01:03:12","date_gmt":"2012-04-14T05:33:12","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=25849"},"modified":"2012-04-14T12:00:32","modified_gmt":"2012-04-14T16:30:32","slug":"ulceras-por-criptococosis-comportamiento-en-un-paciente-inmunodeprimido-por-medicamentos","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/25849","title":{"rendered":"Ulceras por Criptococosis. Comportamiento en un paciente inmunodeprimido por medicamentos"},"content":{"rendered":"<p><em><strong>Jaime Piquero Martin <span style=\"font-size: x-small;\">(Dermatologo)<\/span>, <\/strong><\/em><br \/><em><strong>Carmen L\u00f3pez <span style=\"font-size: x-small;\">(Pat\u00f3logo- Dermatopatologo)<\/span>, <\/strong><\/em><br \/><em><strong>Elsy Cavallera <span style=\"font-size: x-small;\">( Dermatologo- Micologo)<\/span>, <\/strong><\/em><br \/><em><strong>Liset Lage <span style=\"font-size: x-small;\">(Bionalista Micologo)<\/span>. <\/strong><\/em><br \/><span style=\"font-size: x-small;\"><em><strong>Clinica sanatrix &#8211; Instituto de Biomedicina &#8211; Caracas Venezuela<\/strong><\/em><\/span><\/p>\n<p>Paciente de 62 a\u00f1os qui\u00e9n consulta 10\/01\/2012, por \u00falceras de miembros inferiores refractarias a tratamientos m\u00faltiples . Concomitantemente dolores lumbares y de miembros inferiores que le impiden la correcta deambulacion<\/p>\n<p><!--more--><\/p>\n<p><strong>Antecedentes personales:<\/strong> En 1997 presenta insuficiencia renal cr\u00f3nica terminal, manejado con di\u00e1lisis renal. En 1999 en la Universidad de Antioquia, Medell\u00edn- Colombia se le realiza injerto renal proveniente de donante masculino, fallecido por TEC, inmunologicamente compatible, egresando satisfactoriamente . Previamente a los 30 a\u00f1os de edad presenta Artritis reumatoidea deformante, tratada con Indometacina, Meticorten. Paciente relata que la rodilla derecha se le inflamaba frecuentemente y por muchos a\u00f1os se le realizaban infiltraciones (no refiere cual medicamento?) y drenaban liquido sinovial. Sufre de gastritis frecuente por lo cual ha estado hospitalizado en varias oportunidades. Hipertenso tratado con Enalapril. Actualmente recibe Azatriopina y Meticorten.En el a\u00f1o 2009 comienza a presentar ulceras en miembros inferiores de evoluci\u00f3n t\u00f3rpida por lo que acude al Hospital militar y a cl\u00ednica privada donde le diagnostican Criptococosis las cuales no han respondido a tratamientos por cortos periodos ( no refiere cuales).<\/p>\n<p><strong>Antecedentes familiares:<\/strong> Madre diabetica ( fallecida), Padre TBC y fallece por infarto miocardio<\/p>\n<p><strong>Evaluacion Dermatologica :<\/strong> Multiples ulceras en ambos miembros inferiores especialmente en el derecho, donde se aprecian desde ulceras en sacabocados con bordes biselados hasta infiltrantes y otras de aspecto fagedenicos cruentas, sobre tejido cicatricial y multiples bocas fistulosas ( Ver im\u00e1genes clinicas)<\/p>\n<div id='gallery-1' class='gallery galleryid-25849 gallery-columns-2 gallery-size-thumbnail'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06536.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06536-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06537.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06537-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06538.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06538-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06539.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06539-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-2-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-4.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-4-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/EXAMEN-DIRECTO.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/EXAMEN-DIRECTO-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/2-FOTO-DE-CRIPTOCOCOSIS-MUCICARMIN.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/2-FOTO-DE-CRIPTOCOCOSIS-MUCICARMIN-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n<p>&nbsp;<\/p>\n<p>Biopsia: Hiperqueratosis laminar y compacta con focos de fibrina y neutrofilos desintegrados formando \u201cescamocostra\u201d. Epitelio con acantosis irregular moderada y marcada de tipo pseudoepiteliomatosa con espongiosis y exocitosis de linfocitos y neutrofilos con vacuolizacion de la capa basal. Infiltrado inflamatorio de predominio histiocitico los cuales se aprecian vacuolados acompa\u00f1ados de marcada degeneracion mucinosa del colageno y con infiltrado linfoplasmocitario con neutrofilos escasos de disposici\u00f3n intersticial, perivascular superficial y profunda. Fibrosis moderada acompa\u00f1ada de proliferaci\u00f3n vascular con edema epitelial. Se aprecian esporas y levaduras con halo azul que varian entre 5 y 20 micras Hallazgos histologicos compatibles para dermatitis granulomatosa infeccion por criptococosis SP ( patron mucinoso) Coloracion de Giensa, Groccot : Positivo para hongos<\/p>\n<p>( Ver im\u00e1genes histologicas ).<\/p>\n<div id='gallery-2' class='gallery galleryid-25849 gallery-columns-3 gallery-size-thumbnail'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06536.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06536-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06536-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06537.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06537-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06537-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06538.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06538-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06538-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06539.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/DSC06539-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/DSC06539-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-2-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-2-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-4.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/cultivo-micol-4-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/cultivo-micol-4-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/EXAMEN-DIRECTO.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/EXAMEN-DIRECTO-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/EXAMEN-DIRECTO-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/2-FOTO-DE-CRIPTOCOCOSIS-MUCICARMIN.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/2-FOTO-DE-CRIPTOCOCOSIS-MUCICARMIN-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n<p>&nbsp;<\/p>\n<p>Examenes paraclinicos hematologicos y bioquimicos DLN con anisocitosis (+) e hiposegmentados presentes. Proteina C reactiva DLN, Anti HIV negativo, ANA. Negativo ANtiDna , Anti Sm, Anti Ro; Negativos. Complemento C3 y C4 Normal.<\/p>\n<p>&nbsp;<\/p>\n<p>Debido a las condiciones socioeconomicas del paciente se refiere al Instituto de Biomedicina donde es hospitalizado en Hospital Vargas de caracas<\/p>\n<p>&nbsp;<\/p>\n<p>El Laboratorio de Micologia del Instituto de Biomedina le realiza examen directo con tinta china, donde se evidencia una levadura encapsulada t\u00edpica de criptococo. Se toma muestra para cultivo micologico , en donde se puede establecer que se trata de un criptococo spp. Actualmente se han montado los medios especiales para hacer el repique y establecer si trata de un criptococo gattii o un criptococo neoformans var grubi. (1) ( Ver im\u00e1genes micologicas)<\/p>\n<table style=\"width: 300px;\" border=\"0\" cellspacing=\"2\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25854\" title=\"FOTO 2 DE CRIPTOCOCOSIS\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-2-DE-CRIPTOCOCOSIS-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25855\" title=\"FOTO DE CRIPTOCOCOSIS 1\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-1-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25856\" title=\"FOTO DE CRIPTOCOCOSIS 3\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-3-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25857\" title=\"FOTO DE CRIPTOCOCOSIS 4\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-4-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25858\" title=\"FOTO DE CRIPTOCOCOSIS 5\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/FOTO-DE-CRIPTOCOCOSIS-5-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-25862\" title=\"caso-309\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2012\/04\/caso-309-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-150x150.jpg 150w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-290x290.jpg 290w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2012\/04\/caso-309-260x260.jpg 260w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>Se indica terapia sistemica con Fluconazol. En los ex\u00e1menes directos posteriores, recibiendo tratamiento con fluconazol, se evidenciaron levaduras encapsuladas en menor cantidad y con una franca disminuci\u00f3n del grosor de la c\u00e1psula, pero nunca se negativizaron .<\/p>\n<p>La mejoria clinica ha sido satisfactoria pero las ulceras no han cicatrizado. El paciente egresa con ex\u00e1menes directos todav\u00eda positivos, con menor carga f\u00fangica y disminuci\u00f3n del grosor de la c\u00e1psula. Cultivo micologico en medios especiales esta creciendo un Criptococo neoformans var grubbii.<\/p>\n<p>(1) Vivas J, Alvarado P y col. Sinergismo in vitro entre hidrazonas, ajoeno y posaconazol sobre aislados de Crytococcus spp. Invest. Clin. 2011;52(4):312-322<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paciente de 62 a\u00f1os qui\u00e9n consulta 10\/01\/2012, por \u00falceras de miembros inferiores refractarias a tratamientos m\u00faltiples . Concomitantemente dolores lumbares y de miembros inferiores que le impiden la correcta deambulacion<\/p>\n","protected":false},"author":16,"featured_media":25897,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29,574],"tags":[],"class_list":["post-25849","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-caso-de-la-semana","category-seccion-inicial"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/25849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=25849"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/25849\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media\/25897"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=25849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=25849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=25849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}