{"id":36385,"date":"2014-06-20T20:15:20","date_gmt":"2014-06-21T00:45:20","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=36385"},"modified":"2014-06-20T21:42:03","modified_gmt":"2014-06-21T02:12:03","slug":"melanoma-arising-in-association-with-blue-nevus-a-clinical-and-pathologic-study-of-24-cases-and-comprehensive-review-of-the-literature","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/36385","title":{"rendered":"Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature"},"content":{"rendered":"

Mod Pathol.<\/span>\u00a02014 Apr 18. doi: 10.1038\/modpathol.2014.62.<\/span><\/p>\n

<\/p>\n

Loghavi S1<\/sup>,\u00a0Curry JL1<\/sup>,\u00a0Torres-Cabala CA1<\/sup>,\u00a0Ivan D1<\/sup>,\u00a0Patel KP2<\/sup>,\u00a0Mehrotra M2<\/sup>,\u00a0Bassett R3<\/sup>,\u00a0Prieto VG1<\/sup>,\u00a0Tetzlaff MT1<\/sup>.<\/div>\n
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Author information<\/h3>\n
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    \n
  • 1<\/sup>Department of Pathology, Section of Dermatopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.<\/li>\n
  • 2<\/sup>Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.<\/li>\n
  • 3<\/sup>Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
    \n

    Abstract<\/h3>\n
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    Melanomas arising in association with blue nevi or mimicking cellular blue nevi comprise a relatively rare and heterogeneous group of melanomas.<\/span>\u00a0It remains controversial which prognostic indicators predictive of outcome in conventional cutaneous melanomas are applicable to this type of\u00a0melanoma. Here, we describe the clinical and histopathologic features of\u00a024 melanomas\u00a0<\/span><\/b>arising in association with blue nevi and correlate these with clinical outcome. The mean patient age was 49 years (range: 23-85) with a slight female predominance (15 females:9 males). The most common anatomic locations included the head and neck region (50%), the trunk (21%), and the buttock\/sacrococcygeum (17%).\u00a0Histologically, the tumors were typically situated in the mid to deep dermis with variable involvement of the subcutis, but uniformly lacked a prominent intraepithelial component.<\/span>\u00a0The mean tumor thickness (defined as either the standard\u00a0Breslow\u00a0thickness or, if not available due to the\u00a0lack\u00a0of orientation or\u00a0lack\u00a0of epidermis, the largest tumor dimension) was 20.9?mm (range: 0.6-130?mm). The mean mitotic figure count was 6.5\/mm2<\/sup>(range: 1-30\/mm2<\/sup>).\u00a0Perineural invasion was common (38%).<\/span><\/b>\u00a0Follow-up was available for 21 cases (median 2.1 years). The median overall survival, recurrence-free survival, time to local recurrence, and time to distant recurrence were 5.2, 0.7, 2.6, and 1.6 years, respectively. Logistic regression analyses demonstrated a significant association between tumor thickness and recurrence-free survival (hazard ratio=1.02 per mm; P=0.04) and reduced time to distant metastasis (hazard ratio=1.03 per mm; P=0.02) with a similar trend toward reduced time to local recurrence (hazard ratio=1.02 per mm; P=0.07). No other parameters (age, anatomic location, mitotic figures, lymphovascular or perineural invasion, or type of associated blue nevus) emerged as significant. In addition, we provide a comprehensive review of 109 cases of\u00a0melanoma\u00a0blue nevus type described in the English literature and summarize our findings in this context.Modern Pathology advance online publication, 18 April 2014; doi:10.1038\/modpathol.2014.62<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Mod Pathol.\u00a02014 Apr 18. doi: 10.1038\/modpathol.2014.62.<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,1],"tags":[],"class_list":["post-36385","post","type-post","status-publish","format-standard","","category-articulos-cientificos","category-generales"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/36385","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=36385"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/36385\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=36385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=36385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=36385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}