{"id":36393,"date":"2014-06-20T20:11:44","date_gmt":"2014-06-21T00:41:44","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=36393"},"modified":"2014-06-20T21:40:56","modified_gmt":"2014-06-21T02:10:56","slug":"sentinel-lymph-node-biopsy-is-accurate-and-prognostic-in-head-and-neck-melanoma","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/36393","title":{"rendered":"Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma"},"content":{"rendered":"

Cancer.<\/span>\u00a02012 Feb 15;118(4):1040-7. doi: 10.1002\/cncr.26288. Epub 2011 Jul 19.<\/span><\/p>\n

<\/p>\n

Erman AB1<\/sup>,\u00a0Collar RM,\u00a0Griffith KA,\u00a0Lowe L,\u00a0Sabel MS,\u00a0Bichakjian CK,\u00a0Wong SL,\u00a0McLean SA,\u00a0Rees RS,\u00a0Johnson TM,Bradford CR.<\/div>\n
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Author information<\/h3>\n
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    \n
  • 1<\/sup>Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109-5312, USA.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
    \n

    Abstract<\/h3>\n
    \n

    BACKGROUND:<\/h4>\n

    Sentinel lymph node biopsy (SLNB) has emerged as a widely used staging procedure for cutaneous melanoma. However, debate remains around the accuracy and prognostic implications of SLNB for cutaneous melanoma arising in the head and neck, as previous reports have demonstrated inferior results to those in nonhead and neck regions. Through the largest single-institution series of head and neck melanoma patients, the authors set out to demonstrate that SLNB accuracy and prognostic value in the head and neck region are comparable to other sites.<\/p>\n

    METHODS:<\/h4>\n

    A prospectively collected database was queried for cutaneous head and neck melanoma patients who underwent SLNB at the University of Michigan between 1997 and 2007. Primary endpoints included SLNB result, time to recurrence, site of recurrence, and date and cause of death. Multivariate models were constructed for analyses.<\/p>\n

    RESULTS:<\/h4>\n

    Three hundred fifty-three patients were identified. A sentinel lymph node was identified in 352 of 353 patients (99.7%). Sixty-nine of the 353 (19.6%) patients had a positive SLNB. Seventeen of 68 patients (25%) undergoing completion lymphadenectomy after a positive SLNB result had at least 1 additional positive nonsentinel lymph node. Patients with local control and a negative SLNB failed regionally in 4.2% of cases. Multivariate analysis revealed positive SLNB status to be the most prognostic clinicopathologic predictor of poor outcome; hazard ratio was 4.23 for SLNB status and recurrence-free survival (P < .0001) and 3.33 for overall survival (P < .0001).<\/p>\n

    CONCLUSIONS:<\/h4>\n

    SLNB is accurate and its results are of prognostic importance for head and neck melanoma patients<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Cancer.\u00a02012 Feb 15;118(4):1040-7. doi: 10.1002\/cncr.26288. Epub 2011 Jul 19.<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,1],"tags":[],"class_list":["post-36393","post","type-post","status-publish","format-standard","","category-articulos-cientificos","category-generales"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/36393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=36393"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/36393\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=36393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=36393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=36393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}