{"id":41239,"date":"2015-11-06T08:07:54","date_gmt":"2015-11-06T12:37:54","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=41239"},"modified":"2015-11-07T17:10:51","modified_gmt":"2015-11-07T21:40:51","slug":"diet-metabolites-and-western-lifestyle-inflammatory-diseases","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/41239","title":{"rendered":"Diet, Metabolites, and \u2018\u2018Western-Lifestyle\u2019\u2019 Inflammatory Diseases"},"content":{"rendered":"<p><em>Alison N. Thorburn,1,2 Laurence Macia,1,2 and Charles R. Mackay1,*<\/em><br \/>\n<em> 1Department of Immunology, Monash University, Clayton, VIC 3800, Australia<\/em><br \/>\n<em> 2Co-first author<\/em><br \/>\n<em> *Correspondence: charles.mackay@monash.edu<\/em><\/p>\n<p>One explanation for the increased incidence of allergies, asthma, and even some autoimmune diseases has<br \/>\nbeen the hygiene hypothesis. However, recent studies also highlight an important role for diet and bacterial<br \/>\nmetabolites in controlling various immune pathways, including gut and immune homeostasis, regulatory<br \/>\nT cell biology, and inflammation. Dietary-related metabolites engage \u2018\u2018metabolite-sensing\u2019\u2019 G-proteincoupled<br \/>\nreceptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35. These receptors are expressed<br \/>\non immune cells and some gut epithelial cells and generally mediate a direct anti-inflammatory effect. Insufficient<br \/>\nintake of \u2018\u2018healthy foodstuffs\u2019\u2019 adversely affects the production of bacterial metabolites. These metabolites<br \/>\nand those derived directly from food drive beneficial downstream effects on immune pathways. We<br \/>\npropose that insufficient exposure to dietary and bacterial metabolites might underlie the development of<br \/>\ninflammatory disorders in Western countries. This review highlights what is currently known about diet,<br \/>\nmetabolites, and their associated immune pathways in relation to the development of inflammatory disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alison N. Thorburn,1,2 Laurence Macia,1,2 and Charles R. Mackay1,* 1Department of Immunology, Monash University, Clayton, VIC 3800, Australia 2Co-first author *Correspondence: charles.mackay@monash.edu One explanation for the increased incidence of allergies, asthma, and even some autoimmune diseases has been the hygiene hypothesis. However, recent studies also highlight an important role for diet and bacterial metabolites in &hellip;<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-41239","post","type-post","status-publish","format-standard","","category-articulos-cientificos"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/41239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=41239"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/41239\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=41239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=41239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=41239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}