J Clin Psychopharmacol. 2016 Feb;36(1):57-62. doi: 10.1097\/JCP.0000000000000431.<\/p>\n
Smith L1, Tracy DK, Giaroli G.<\/p>\n
Author information<\/strong> Licensed pharmacological treatments for obsessive-compulsive disorders include selective serotonin reuptake inhibitors and tricyclic antidepressants. However, a large proportion of patients show minimal or no therapeutic response to these treatments. The glutamatergic system has been implicated in the etiology of obsessive-compulsive spectrum disorders, and it has been postulated that n-acetyl-cysteine (NAC) could have a therapeutic effect on these conditions through its actions on the glutamatergic system and the reduction of oxidative stress. A systematic review was conducted on the existing methodologically robust literature regarding the efficacy of NAC on obsessive-compulsive spectrum disorders in adults and children. Four randomized, double-blind placebo-controlled studies were identified, investigating the effects of NAC on obsessive-compulsive disorder, trichotillomania, and onychophagia. Results remain inconclusive, but NAC may still be useful as a treatment for obsessive-compulsive spectrum disorders on an individual level, particularly as the compound has a relatively benign side-effect profile. The dearth of methodologically robust work is clinically important: larger randomized controlled trials are required to inform of any meaningful clinical effectiveness, and to better determine which, if any, clinical populations might most benefit. J Clin Psychopharmacol. 2016 Feb;36(1):57-62. doi: 10.1097\/JCP.0000000000000431. Smith L1, Tracy DK, Giaroli G. Author information Abstract Licensed pharmacological treatments for obsessive-compulsive disorders include selective serotonin reuptake inhibitors and tricyclic antidepressants. However, a large proportion of patients show minimal or no therapeutic response to these treatments. The glutamatergic system has been implicated in the etiology of …<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-41651","post","type-post","status-publish","format-standard","","category-articulos-cientificos"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/41651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=41651"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/41651\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=41651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=41651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=41651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n Abstract<\/strong><\/p>\n
\nComentarios:
\nEl uso de f\u00e1rmaco con acetilciste\u00edna provoca un alivio sintom\u00e1tico de las afecciones del tracto respiratorio en los que se produce una producci\u00f3n excesiva de moco. Suele administrarse mediante uso oral: Sobres, comprimidos efervescentes, jarabes, etc.o por v\u00eda parenteral: Intramuscular, intravenosa, etc. Existen f\u00e1rmacos que permiten adminsistrar la acetilcisteina de forma inhalatoria. Se comercializa bajo los nombres de Aflux\u00ae, Fluimucil\u00ae, Lisomucil\u00ae, Flumil\u00ae. Tambi\u00e9n se usa en el tratamiento de la intoxicaci\u00f3n por paracetamol1 y m\u00e1s recientemente como coadyuvante en el tratamiento de la fibrosis pulmonar.2 Tiene como complemento la acci\u00f3n funcional en el sistema excretor, corrigiendo intoxicaciones inducidas por medicamentos administrados en procedimientos intrahospitalarios (medios de contraste) utilizados en estudios contrastados para mejorar visibilidad de los \u00f3rganos, y medio de diagn\u00f3stico muy utilizado debido a su eficacia.<\/p>\n","protected":false},"excerpt":{"rendered":"