{"id":42729,"date":"2016-06-24T13:05:39","date_gmt":"2016-06-24T17:35:39","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=42729"},"modified":"2016-06-24T19:56:23","modified_gmt":"2016-06-25T00:26:23","slug":"efficacy-and-possible-mechanisms-of-topical-tranexamic-acid-in-melasma","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/42729","title":{"rendered":"Efficacy and possible mechanisms of topical tranexamic acid in melasma"},"content":{"rendered":"<p><!--more--><\/p>\n<h3>Summary<\/h3>\n<div>\n<h4>Background<\/h4>\n<div>\n<p>Tranexamic acid (TA) has been suggested as an effective treatment for melasma.<\/p>\n<\/div>\n<\/div>\n<div>\n<h4>Aim<\/h4>\n<div>\n<p>To investigate the effects and mechanism of action of topical TA in the treatment of melasma.<\/p>\n<\/div>\n<\/div>\n<div>\n<h4>Methods<\/h4>\n<div>\n<p>In this study, 23 participants with melasma applied a 2% TA formulation to the whole face for 12 weeks. Clinical effects were evaluated using the modified Melasma Area and Severity Index (mMASI) and a chromameter. Skin biopsies were obtained from 10 participants to evaluate pigmentation, vascularity and the expression levels of possible paracrine factors contributing to the effect of TA.<\/p>\n<\/div>\n<\/div>\n<div>\n<h4>Results<\/h4>\n<div>\n<p>Most of the participants had mild melasma, with mMASI of &lt; 5. The mMASI scores significantly improved in 22 of 23 participants after application. The L* values were increased and the a* values were decreased in both lesional and perilesional normal skin. Fontana\u2013Masson staining showed a significant decrease in melanin content in the epidermis. The number of CD31-positive vessels and the expression of the vascular endothelial growth factor both tended to decrease. Endothelin (ET)-1 was found to be downregulated with TA.<\/p>\n<\/div>\n<\/div>\n<div>\n<h4>Conclusions<\/h4>\n<div>\n<p>Topical TA is effective for melasma. This immunohistochemical study found that suppression of ET-1 could be one of the mechanisms of action of TA on melasma.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42729","post","type-post","status-publish","format-standard","","category-articulos-cientificos"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/42729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=42729"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/42729\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=42729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=42729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=42729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}