{"id":5196,"date":"2008-12-05T23:17:51","date_gmt":"2008-12-06T03:17:51","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=5196"},"modified":"2008-12-05T23:24:16","modified_gmt":"2008-12-06T03:24:16","slug":"consulta-a-un-colega-n2-enfermedad-de-flegel-hiperqueratosis-lenticularis-perstans","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/5196","title":{"rendered":"Consulta a un Colega N\u00ba2: Enfermedad de Flegel. Hiperqueratosis lenticularis perstans."},"content":{"rendered":"

 Dres . Jaime Piquero Mart\u00edn, Edgar la Rotha
\nCl\u00ednica de la piel ( Cl\u00ednica Sanatrix). Caracas Venezuela<\/strong><\/p>\n

Paciente femenina de 40 a\u00f1os natural y procedente de Ocumare del Tuy quien consulta por presentar lesiones hiperqueratosicas asintom\u00e1ticas de 6 a\u00f1os de evoluci\u00f3n. Las lesiones se aprecian en ambas piernas y se extienden progresivamente a muslos y gl\u00fateos. Antecedentes familiares y personales no contributorios.<\/p>\n

Descripci\u00f3n: M\u00faltiples p\u00e1pulas redondeadas de 3 – 5 mm de borde bien delimitado con descamaci\u00f3n fina en su superficie. Al retirar la lesi\u00f3n se aprecia zona sangrante y maculas hipocromicas.<\/p>\n

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\nel infiltrado y la vacuolizacion suyacente a epidermis adelgazada con paraqueratosis e hipogranulosis<\/p>\n

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\nfoco de epidermis invaginada<\/p>\n

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\ninaginacion con paraqueratosis hipogranulosis adegazamiento del epitelio<\/p>\n

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\ninfiltrado liquenoide y vacuolizacion focal<\/p>\n

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Esta paciente fue previamente evaluada y exhaustivamente estudiada por la  Dra. Elizabeth Ball, hace  5 a\u00f1os y manejada con \u00e9xito  con 5- fluoracilo y presentado en la revista “Dermatolog\u00eda venezolana” ( Dermat Venez vol 42 N* 2, 2004)<\/p>\n

http:\/\/svdcd.org.ve\/revista\/2004\/42\/2\/DV-2-04-Art-Flegel.pdf<\/a><\/p>\n

La paciente refiere que al parar el 5-fluoracilo regresan las lesiones<\/p>\n

\u00bf;Qu\u00e9 sugieren como alternativas de manejo?<\/strong><\/span><\/p>\n

Ultimo art\u00edculo publicado: Int J Dermatol. 2008 Nov;47 Suppl 1:38-41.<\/p>\n

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Hyperkeratosis lenticularis perstans (Flegel’s disease) – successful treatment with topical corticosteroids.<\/strong><\/p>\n

Sterneberg-Vos H<\/strong>, van Marion AM<\/strong>, Frank J<\/strong>, Poblete-Gutierrez P<\/strong>.<\/p>\n

Department of Dermatology, and Maastricht University Center for Molecular Dermatology, University Medical Center Maastricht, The Netherlands. hmv@sder.azm.nl<\/a><\/p>\n

Flegel’s disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate. Treatment is difficult and rarely fully effective. We report on a woman with Flegel’s disease who responded to a topical corticosteroid therapy with betamethasone dipropionate.<\/p>\n<\/blockquote>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

 Dres . Jaime Piquero Mart\u00edn, Edgar la Rotha Cl\u00ednica de la piel ( Cl\u00ednica Sanatrix). Caracas Venezuela Paciente femenina de 40 a\u00f1os natural y procedente de Ocumare del Tuy quien consulta por presentar lesiones hiperqueratosicas asintom\u00e1ticas de 6 a\u00f1os de evoluci\u00f3n. Las lesiones se aprecian en ambas piernas y se extienden progresivamente a muslos y …<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[256],"class_list":["post-5196","post","type-post","status-publish","format-standard","","category-consulte-a-un-colega","tag-enfermedad-de-flegel"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/5196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=5196"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/5196\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=5196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=5196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=5196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}