{"id":52508,"date":"2024-03-25T11:12:29","date_gmt":"2024-03-25T15:12:29","guid":{"rendered":"https:\/\/piel-l.org\/blog\/?p=52508"},"modified":"2024-03-25T11:12:29","modified_gmt":"2024-03-25T15:12:29","slug":"capitulo-2-bases-fisiopatologicas-del-acne","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/52508","title":{"rendered":"<Libro Acn\u00e9> Cap\u00edtulo 2. Bases fisiopatol\u00f3gicas del acn\u00e9"},"content":{"rendered":"<p>Desde hace algunos a\u00f1os la patogenia del acn\u00e9 se aceptaba y aun se acepta en forma esquem\u00e1tica en cuatro pilares:<\/p>\n<ul>\n<li>Producci\u00f3n de sebo<\/li>\n<li>Anormal queratinizaci\u00f3n del fol\u00edculo piloseb\u00e1ceo,<\/li>\n<li>Proliferaci\u00f3n de Propionibacterium acn\u00e9s, hoy en d\u00eda Cutibacterium acn\u00e9s.<\/li>\n<li>Cambios inmunol\u00f3gicos.<\/li>\n<\/ul>\n<p>Se dec\u00eda y se dice que la estimulaci\u00f3n de andr\u00f3genos sobre la gl\u00e1ndula seb\u00e1cea aumenta la cantidad y calidad de sebo y a su vez estimula al queratinocito generando una hiperqueratinizaci\u00f3n anormal; ambos generan una obstrucci\u00f3n del fol\u00edculo seb\u00e1ceo lo que permite la proliferaci\u00f3n del Cutibacterium acnes (C. acnes), todo ello desencadena una liberaci\u00f3n de citoquinas\u00a0 que se expresan cl\u00ednicamente con inflamaci\u00f3n.<\/p>\n<a href=\"https:\/\/drive.google.com\/file\/d\/1XXpA-o5-SRVNzim2lpbd44prXAsf4BTS\/view?usp=sharing\" class=\"su-button su-button-style-flat su-button-wide\" style=\"color:#ffffff;background-color:#131ed0;border-color:#1018a7;border-radius:8px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#ffffff;padding:7px 22px;font-size:17px;line-height:26px;border-color:#5a62df;border-radius:8px;text-shadow:none\"><i class=\"sui sui-file-pdf-o\" style=\"font-size:17px;color:#ffffff\"><\/i> VER PRESENTACI\u00d3N COMPLETA<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"<p>Libro: ACNE, Experiencia: Pasado, Presente y Futuro<br \/>\n<strong>Jaime Piquero-Mart\u00edn<\/strong><\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[564],"tags":[],"class_list":["post-52508","post","type-post","status-publish","format-standard","","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/52508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=52508"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/52508\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=52508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=52508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=52508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}