{"id":6971,"date":"2009-03-20T20:03:30","date_gmt":"2009-03-21T00:03:30","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=6971"},"modified":"2009-03-20T21:12:00","modified_gmt":"2009-03-21T01:12:00","slug":"hyperinsulinemic-diseases-of-civilization-more-than-just-syndrome-x","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/6971","title":{"rendered":"Hyperinsulinemic diseases of civilization: more than just Syndrome X"},"content":{"rendered":"<p><em><strong>Cordialmente enviado por Dra. Isabel Arias G\u00f3mez<\/strong><\/em><\/p>\n<p>Cordain L, Eades M, Eades M. Hyperinsulinemic diseases of civilization: more than just s\u00ed\u00adndrome X Comp. biochemistry and Physiology Part A. 2003. 136: 95\u00a0 112<br \/>\n \u00abConsidero la dieta\u00a0 un factor\u00a0 adicional en la etiopatogenia del acn\u00e9. Los invitamos a asistir y participar en Radla 2009 en la ciudad de Mexico\u00bb<br \/>\n Dra. Isabel Arias G\u00f3mez<\/p>\n<p><!--more--><\/p>\n<p>Abstract<br \/>\n Compensatory hyperinsulinemia stemming from peripheral insulin resistance is a well-recognized metabolic disturbance that is at the root cause of diseases and maladies of Syndrome X (hypertension, type 2 diabetes, dyslipidemia, coronary artery disease, obesity, abnormal glucose tolerance). Abnormalities of fibrinolysis and hyperuricemia also appear to be members of the cluster of illnesses comprising Syndrome X. Insulin is a well-established growth-promoting hormone, and recent evidence indicates that hyperinsulinemia causes a shift in a number of endocrine pathways that may favor unregulated tissue growth leading to additional illnesses. Specifically, hyperinsulinemia elevates serum concentrations of free insulin-like growth factor-1 (IGF-1) and androgens, while simultaneously reducing insulin-like growth factor-binding protein 3 (IGFBP-3) and sex hormone-binding globulin (SHBG). Since IGFBP-3 is a ligand for the nuclear retinoid X receptor a, insulin-mediated reductions in IGFBP-3 may also influence transcription of anti-proliferative genes normally activated by the body\u00e2\u20ac\u2122s endogenous retinoids. These endocrine shifts alter cellular proliferation and growth in a variety of tissues, the clinical course of which may promote acne, early menarche, certain epithelial cell carcinomas, increased stature, myopia, cutaneous papillomas (skin tags), acanthosis nigricans, polycystic ovary syndrome (PCOS) and male vertex balding. Consequently, these illnesses and conditions may, in part, have hyperinsulinemia at their root cause and therefore should be classified among the diseases of Syndrome X.<\/p>\n<p>__________________<\/p>\n<p><em>Si el suscritor de Piel latinoamericana desea el art\u00c3\u00adculo completo favor contactar a los Editores<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cordialmente enviado por Dra. Isabel Arias G\u00f3mez Cordain L, Eades M, Eades M. Hyperinsulinemic diseases of civilization: more than just s\u00ed\u00adndrome X Comp. biochemistry and Physiology Part A. 2003. 136: 95\u00a0 112 \u00abConsidero la dieta\u00a0 un factor\u00a0 adicional en la etiopatogenia del acn\u00e9. Los invitamos a asistir y participar en Radla 2009 en la ciudad &hellip;<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-6971","post","type-post","status-publish","format-standard","","category-articulos-cientificos"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/6971","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=6971"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/6971\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=6971"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=6971"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=6971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}