{"id":7041,"date":"2009-03-27T23:49:28","date_gmt":"2009-03-28T03:49:28","guid":{"rendered":"http:\/\/piel-l.org\/blog\/?p=7041"},"modified":"2009-03-28T00:51:07","modified_gmt":"2009-03-28T04:51:07","slug":"229-consulta-a-un-colega-n1-mi-primera-experiencia-con-derivados-biologicos-infliximab-ano-2004","status":"publish","type":"post","link":"https:\/\/piel-l.org\/blog\/7041","title":{"rendered":"229 &#8211; Consulta a un Colega N\u00ba1: Mi primera experiencia con derivados biol\u00f3gicos. INFLIXIMAB. A\u00f1o 2004"},"content":{"rendered":"<p><em><strong>Dra. Raquel M Ramos M. Centro Policl\u00ednico Valencia, La Vi\u00f1a.<br \/>\n Dr. Jos\u00e9 A. Corado Ram\u00edrez. Centro Docente de Urolog\u00eda. Valencia<\/strong><\/em><\/p>\n<p>Se procede a la administraci\u00f3n de Infliximab en forma de infusi\u00f3n, previa administraci\u00f3n de Clomfeniramina, a raz\u00f3n de 3 mg\/kgp a paciente masculino de 25 a\u00f1os de edad , que pesa 100 kg,con diagn\u00f3stico de Artritis Psori\u00e1tica. de 2 a\u00f1os de evoluci\u00f3n.<\/p>\n<p><!--more--><\/p>\n<p>Antecedentes Personales Patol\u00f3gicos:<\/p>\n<p>1997. Cuadro articular en rodillas que es atribuido a sobrepeso del paciente.<\/p>\n<p>2002: Aparici\u00f3n de placas psori\u00e1ticas seguidas de cuadro articular. En diciembre de ese a\u00f1o de le administra Neotygason, sin previa realizaci\u00f3n de monitoreo hep\u00e1tico. Al realizarse este, se encuentra elevaci\u00f3n de transaminasas a nivel de alarma.<\/p>\n<p>2003: Interconsulta con inmunolog\u00eda .<\/p>\n<p>Ecogr\u00e1fico: Hepatomegalia<\/p>\n<p>Biopsia Hep\u00e1tica: Fibrosis portal leve, esteatosis hep\u00e1tica leve, multifocal. Infiltrado inflamatorio moderado linfoc\u00edtico portal: HEPATITIS REACTIVA INESPEC\u00cdFICA<\/p>\n<p>Ex\u00e1menes Inmunol\u00f3gicos:<\/p>\n<p>Anticuerpos antinucleates + difuso <br \/>\n Anticuerpos antimitocondriales \u2013 <br \/>\n Anticuerpos antim\u00fasculo liso + (2 veces) <br \/>\n LC1 \u2013 <br \/>\n LKM1 \u2013 <br \/>\n ANCA- <br \/>\n Ra test  &#8211;<\/p>\n<p>Ex Laboratorio:<\/p>\n<p>HB 11,66    Gb: 11.200 63% neutr\u00f3filos 39% linfocitos <br \/>\n VSG. 120 mm\/h <br \/>\n TGP 75  TGO 25 <br \/>\n Glicemia: 70 mg\/dl <br \/>\n Colesterol: 200    Triglic\u00e9ridos 100 <br \/>\n Prote\u00edna C Reactiva \u2013 <br \/>\n VDRL No reactivo     HIV \u2013<\/p>\n<p>A los 2 meses hace cuadro poliarticular que origina impotencia funcional de 3 semanas de evoluci\u00f3n, seguido de empeoramiento cut\u00e1neo.<\/p>\n<p>CON LOS DIAGNOSTICOS DE ARTRITIS PSORIATICA Y HEPATITIS AUTOINMUNE, se decide administraci\u00f3n de la droga, en las semanas 0. 4, 8  .<\/p>\n<p>Fotos cl\u00ednicas:<\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-7042 alignnone\" title=\"foto1\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto1-300x183.jpg\" alt=\"foto1\" width=\"300\" height=\"183\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto1-300x183.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto1.jpg 704w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7043\" title=\"foto2\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto2-300x271.jpg\" alt=\"foto2\" width=\"300\" height=\"271\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto2-300x271.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto2.jpg 742w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7044\" title=\"foto3\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto3-268x300.jpg\" alt=\"foto3\" width=\"268\" height=\"300\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto3-268x300.jpg 268w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto3.jpg 296w\" sizes=\"auto, (max-width: 268px) 100vw, 268px\" \/><\/a><\/p>\n<p>Semana 8:<\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7045\" title=\"foto4\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto4-300x268.jpg\" alt=\"foto4\" width=\"300\" height=\"268\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto4-300x268.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto4.jpg 741w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7046\" title=\"foto5\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto5-300x188.jpg\" alt=\"foto5\" width=\"300\" height=\"188\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto5-300x188.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto5.jpg 986w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Histopatolog\u00eda:<\/p>\n<p>Piel<\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7047\" title=\"foto6\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto6-300x236.jpg\" alt=\"foto6\" width=\"300\" height=\"236\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto6-300x236.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto6.jpg 613w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>H\u00edgado<\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7048\" title=\"foto7\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto7-300x115.jpg\" alt=\"foto7\" width=\"300\" height=\"115\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto7-300x115.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto7-1024x392.jpg 1024w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto7.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto8.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7049\" title=\"foto8\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto8-300x116.jpg\" alt=\"foto8\" width=\"300\" height=\"116\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto8-300x116.jpg 300w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto8-1024x398.jpg 1024w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto8.jpg 1209w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7051\" title=\"conclu\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/conclu.gif\" alt=\"conclu\" width=\"522\" height=\"365\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/conclu.gif 522w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/conclu-300x209.gif 300w\" sizes=\"auto, (max-width: 522px) 100vw, 522px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7050\" title=\"foto9\" src=\"http:\/\/piel-l.org\/blog\/wp-content\/uploads\/\/2009\/03\/foto9.jpg\" alt=\"foto9\" width=\"326\" height=\"394\" srcset=\"https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto9.jpg 326w, https:\/\/piel-l.org\/blog\/wp-content\/uploads\/2009\/03\/foto9-248x300.jpg 248w\" sizes=\"auto, (max-width: 326px) 100vw, 326px\" \/><\/p>\n<p><br class=\"spacer_\" \/><\/p>\n<p><br class=\"spacer_\" \/><\/p>\n<p><br class=\"spacer_\" \/><\/p>\n<p><br class=\"spacer_\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dra. Raquel M Ramos M. Centro Policl\u00ednico Valencia, La Vi\u00f1a. Dr. Jos\u00e9 A. Corado Ram\u00edrez. Centro Docente de Urolog\u00eda. Valencia Se procede a la administraci\u00f3n de Infliximab en forma de infusi\u00f3n, previa administraci\u00f3n de Clomfeniramina, a raz\u00f3n de 3 mg\/kgp a paciente masculino de 25 a\u00f1os de edad , que pesa 100 kg,con diagn\u00f3stico de &hellip;<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-7041","post","type-post","status-publish","format-standard","","category-consulte-a-un-colega"],"_links":{"self":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/7041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/comments?post=7041"}],"version-history":[{"count":0,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/posts\/7041\/revisions"}],"wp:attachment":[{"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/media?parent=7041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/categories?post=7041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/piel-l.org\/blog\/wp-json\/wp\/v2\/tags?post=7041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}