Simpkin S, Oakley A.
Department of Dermatology, Waikato Hospital, Hamilton, New Zealand.
A 67-year-old man with chronic plaque psoriasis previously treated with psoralen plus PUVA, ciclosporin, methotrexate and acitretin developed eruptive squamous cell carcinoma after seven doses of adalimumab. We review the association of squamous cell carcinoma with immunosuppressive agents used for the treatment of chronic plaque psoriasis. Initiation of tumour necrosis factor (TNF)-? inhibitors in a patient at high risk of non-melanoma skin cancer may warrant chemoprophylaxis with acitretin.
© 2012 The Authors Australasian Cancer Res. 2012 Jul 1;72(13):3282-9.