Risk of Cancer among Commercially Insured HIV-Infected Adults on Antiretroviral Therapy

J Cancer Epidemiol. 2016;2016:2138259. Epub 2016 Nov 2.
Risk of Cancer among Commercially Insured HIV-Infected Adults on Antiretroviral Therapy.

Lee JY1, Dhakal I2, Casper C3, Noy A4, Palefsky JM5, Haigentz M6, Krown SE7, Ambinder RF8, Mitsuyasu RT9.

Abstract

The objective of this study was to explore the cancer incidence rates among HIV-infected persons with commercial insurance who were on antiretroviral therapy and compare them with those rates in the general population. Paid health insurance claims for 63,221 individuals 18 years or older, with at least one claim with a diagnostic code for HIV and at least one filled prescription for an antiretroviral medication between January 1, 2006, and September 30, 2012, were obtained from the LifeLink® Health Plan Claims Database. The expected number of cancer cases in the general population for each gender-age group (<30, 30-39, 40-49, 50-59, and >60 years) was estimated using incidence rates from the Surveillance Epidemiology and End Results (SEER) program. Standardized incidence ratios (SIRs) were estimated using their 95% confidence intervals (CIs). Compared to the general population, incidence rates for HIV-infected adults were elevated (SIR, 95% CI) for Kaposi sarcoma