The use of dermatoscopy to monitor therapeutic response of Bowen’s disease: A dermatoscopic pathological study

Br J Dermatol. 2012 Jul 3. doi: 10.1111/j.1365-2133.2012.11124.x. 
Mun JH, Park JM, Song M, Jwa SW, Kim HS, Ko HC, Kim BS, Kim MB.

Department of Dermatology, School of Medicine, Pusan National University Hospital, Busan, Korea Medical Research Institute, Pusan National University Hospital, Busan, Korea Department of Dermatology, Pusan National University Yangsan Hospital, Gyeongsangnam-do, Korea.

Abstract

Dermatoscopy is a non-invasive technique that can be helpful in the diagnosis of pigmented and non-pigmented?Background: skin A total of 23 patients with 29 histopathologically diagnosed BD lesions were included in this study. After treatment, dermatoscopic examination revealed the disappearance of pre-existing vascular structures in 16 lesions, and remaining vascular structures in 13 lesions. Histopathological evaluation of the treated lesions showed remnant intraepithelial? Patients with histopathologically diagnosed BD were prospectively enrolled. In all lesions, 3 months after the end of treatment (photodynamic therapy or 5% imiquimod cream), dermatoscopic and histopathological examinations were repeated to evaluate and correlate changes in dermatoscopic features and histopathological results. Cured lesions were monitored using dermatoscopy during the follow-up period. Results:? To evaluate the usefulness of dermatoscopy as a tool to assess responses to therapy and recurrence of BD. Methods:?tumours. The dermatoscopic evaluation of Bowen’s disease (BD) improves diagnostic accuracy. Objective: neoplasms Our study results demonstrate that the persistence of dermatoscopic vascular structures of BD appears to be associated with residual disease, and disappearance of vascular structures suggests that the disease has been cured. In addition, reappearance of previous dermatoscopic vascular structures indicates the recurrence of BD. Therefore, we suggest that dermatoscopy can be a useful, reliable, and non-invasive tool in the therapeutic follow-up of BD?and increased dermal vascularity in lesions with persistent dermatoscopic vascular structures. However, normal epidermis and decreased dermal vascularity were observed in all but 1 of the lesions without previous dermatoscopic vascular structures. During the follow-up period, 1 lesion showed reappearance of previous vascular structures on dermatoscopy at 9 months after treatment. Histopathological examination confirmed the recurrence of BD. Conclusions:

Australas J Dermatol. 2012 Jul 3. doi: 10.1111/j.1440-0960.2012.00920.x.