Off-Label Uses of retinoids in dermatology

Artículo enviado para Piel-Latinoamericana por Piotr Brzezinski – Our Dermatology Online gracias a Dra. Patricia Chang.

Wei Li1, Ying Liu1, Quan Luo1, Xue-Mei Li2, Xi-Bao Zhang1
1Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, PR of China
2Department of Dermatology, Guangzhou Women and Children’ s Medical Center, Guangzhou, PR of Chinab

Abstract

Retinoids has been used widely in the topical and systemic treatments of various dermatoses: psoriasis, disorders of keratinization (DOK), keratotic genodermatosis, and severe acne. Moreover, it is also used in the treatment and/or chemoprevention of skin cancer and other neoplasms. Retinoids display key regulatory functions and most dermatologists are familiar with the FDA-approved indication of this medication. Retinoic acid is a potent signaling molecule that is essential for many biological processes, and its levels are tightly regulated by mechanisms that are only partially understood. This article will review these recent findings and attempt to synthesize their meaning to provide a view into the off-label uses of retinoids in dermatology with an emphasis on oral isotretinoin and acitrein.

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