Inicio / De Interés / Artículos Científicos / Variants of Sporothrix schenckii with attenuated virulence for mice

Variants of Sporothrix schenckii with attenuated virulence for mice

(PMID:12941384)
de Lima RF , Schäffer GV , Borba Cde M
Department of Mycology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, FIOCRUZ, CP 926, Rio de Janeiro, RJ 21045-900, Brazil.
Microbes and Infection / Institut Pasteur [2003, 5(11):933-938] Type: Journal Article
DOI: 10.1016/S1286-4579(03)00181-3
Abstract

Strains of Sporothrix schenckii preserved under mineral oil were examined for virulence in BALB/c mice. The mice were inoculated with S. schenckii conidia and development of cutaneous lesions, signs of inactivity, weight loss, survival rates, number of viable yeast cells in lung and spleen, splenomegaly and organ lesions were evaluated. After intravenous injection of 7.5 x 10(6) conidia, two of five S. schenckii strains were unable to induce systemic disease and to kill the mice, only producing cord-like lesions on the tail that regressed with mouse maturation. Very small numbers of viable cells isolated from the spleen confirmed the lower invasive ability of these strains when compared with other strains studied here. These results suggest a relationship between the attenuation of virulence and the storage method under mineral oil after long periods of time.

Acerca de PIEL-L

Mesa de redacción de Piel Latinoamericana. Donde recibimos casos, aportes e información de interés para la comunidad latinoamericana dermatólogica

Deja un comentario

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *

Este sitio web utiliza cookies para que usted tenga la mejor experiencia de usuario. Si continúa navegando está dando su consentimiento para la aceptación de las mencionadas cookies y la aceptación de nuestra política de cookies, pinche el enlace para mayor información.plugin cookies

ACEPTAR
Aviso de cookies