The reviewers looked for evidence from randomized controlled trials (RCTs) on the effects of systemic and topical antibiotics, and topical antiseptics, on pressure ulcer healing in any clinical setting. They found 12 relevant trials with 576 participants, all assessing topical agents: povidone iodine, cadexomer iodine, gentian violet, lysozyme, silver dressings, honey, pine resin, polyhexanide, silver sulfadiazine, and nitrofurazone with ethoxy-diaminoacridine. They were compared with alternative antimicrobials or other ointments and dressings.