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Artículos Científicos

Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers

Vismodegib (GDC-0449) is a small, orally administrable molecule, belonging to the 2-arylpyridine class, which was discovered by Genentech Inc under a collaboration with Curis Inc. Vismodegib inhibits the Hedgehog (Hh) pathway, which is involved in tumorigenesis, thus providing a strong rationale for its use in the treatment of a variety of cancers.

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Efficacy and safety of vismodegib in advanced basal-cell carcinoma

Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among patients with advanced basal-cell carcinoma.

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Artículos Cientiíficos Edición 302

Clinical end points and response criteria in mycosis fungoides and sezary syndrome: a consensus statement of the international society for cutaneous lymphomas, the United States cutaneous lymphoma consortium, and the cutaneous lymphoma task force of the European organisation for research and treatment of cancer. [Descargar] An unusual adverse effect of …

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Artículos Científicos Edición 301

Adapalene 0.1%/benzoyl peroxide 2.5% gel: a review of its use in the treatment of acne vulgaris in patients aged ?12 years (Leer) Increases in Melanoma Among Adolescent Girls and Young Women in California (Leer) Congenital Dermatofibrosarcoma Protuberans in a Newborn Infant With a Massive Back Tumor: Favorable Effects of Oral …

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Artículos Científicos Edición 298

O uso da oxibutinina no tratamento da hiperidrose facial. [Leer]. Avanços no tratamento da leishmaniose tegumentar do novo mundo nos últimos dez anos: uma revisão sistemática da literatura. [Leer]. Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials. [Leer]. New or unusual dermatopathology …

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Artículos para la Edición 289

Induced Pluripotent Stem Cells from Individuals with Recessive Dystrophic Epidermolysis Bullosa. Journal of Investigative Dermatology (2011) 131, 848–856; doi:10.1038/jid.2010.346; published online 2 December 2010 RANK Is Expressed in Metastatic Melanoma and Highly Upregulated on Melanoma-Initiating Cells. Journal of Investigative Dermatology (2011) 131, 944–955; doi:10.1038/jid.2010.377; published online 27 January 2011 Photodynamic …

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